Q-redox state

Q-redox state

The Q-redox state reflects the redox state of Coenzyme Q (CoQ, ubiquinone and plastoquinone) in the mitochondrial or chloroplast electron transfer system ETS. Q represents these mobile redox components located centrally at the Q-junction of the mitochondrial respiratory ETS and the chloroplast photosynthesis system.

In mitochondria, the Q-redox state depends on the balance between reducing capacities of convergent electron entries from fuel substrates into the Q-junction and oxidative capacities downstream of Q with the final electron acceptor oxygen. Therefore, deficiencies in the mitochondrial ETS, originating from e.g. the malfunction of respiratory Complexes, can be diagnosed more precisely when combining respiratory measurements with continuous monitoring of the Q-redox state.

The Q-Module of the NextGen-O2k has been developed for measuring the Q redox state simultaneously with respiration in isolated mitochondria and chloroplasts, permeabilized cells, and animal and plant tissues. The Q-Module and the NADH-Module extend high-resolution respirometry to advance state-of-the-art RedoxBiology.

Meet the expert

Luiza Cardoso, PhD
PostDoc, Mitochondrial Wizard

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Tímea Komlódi, PhD
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