The OROBOROS Oxygraph-2k
- to explore the Power of Life
for high-resolution respirometry (HRR)
O2k with simultaneous fluorometry: HRR and ROS production, mt-membrane potential, ATP-production, Ca2+
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O2k high-output, low running costs.
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O2k - the world's most Powerful, Popular and Prestigeous respirometer for cellular and mitochondrial research:
Isolated mitochondria, Intact cells, Permeabilized cells, Permeabilized tissues, Tissue homogenates, Small tissue biopsies
O2k for OXPHOS analysis with substrate-uncoupler-inhibitor titration (SUIT) protocols to study multiple respiratory states in a single experimental incubation: no other platform is suited for application of SUIT protocols.
'OXPHOS analysis extends simple bioenergetics to the level of mitochondrial physiology' (Gnaiger 2012).
O2k - flexibility within experiments, on-line display of concentration and flux, automatic software controlled titrations.
Reference: Gnaiger E (2008) Polarographic oxygen sensors, the oxygraph and high-resolution respirometry to assess mitochondrial function. In: Mitochondrial Dysfunction in Drug-Induced Toxicity (Dykens JA, Will Y, eds) John Wiley: 327-352.
>> More details? Consult TIP2k
O2k - standard for diagnosis of mitochondrial function in health and disease - when there is little room for error.
Reference: Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibres from small biopisies of human muscle. Methods Mol Biol 810: 25-58.
HRR since 1992: Gnaiger E, Steinlechner-Maran R, Mιndez G, Eberl T, Margreiter R (1995) Control of mitochondrial and cellular respiration by oxygen. J Bioenerg Biomembr 27: 583-596.
O2k-MultiSensor: Combining HRR with fluorometry (ROS production, mt-membrane potential, ATP-production, Ca2+), potentiometric measurement of pH, TPP+ and Ca2+, amperometric measurement of NO.
O2k-Fluorescence; O2k-TPP and TPMP; O2k-pH; O2k-NO
get O2k-Connected .. it's not Warburg, it's O2k
>> O2k versus XFe - why it matters
OROBOROS - Top 10 Reasons: Leading technology, sole source, long-term experience, economical, no investors, no expensive advertising, scientific committment, Corporate Social Responsibility ...
- a new Quality in Science
O2k-Feedback: 'Once you've had a taste of high-performance, there's no going back'.
Back from Everest Base Camp and Kathmandu with 5 O2k
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►Bioblast ►O2k-Catalogue ►O2k-Fluorescence
►MitoPedia Glossary: Respiratory states